731 RISK OF ESOPHAGEAL AND GASTRIC ADENOCARCINOMA IN MEN RECEIVING ANDROGEN DEPRIVATION THERAPY FOR PROSTATE CANCER

Abstract There is an unexplained male predominance in the incidence of esophageal (EAC) and non-cardia gastric adenocarcinoma (GAC) which cannot be explained by known risk factors. Differences exposures to sex hormones may play a part observed difference. This study aimed test hypothesis that androgens increase EAC, cardia GAC, GAC. We analysed matched cohort based on national Swedish database prostate cancer patients. Methods Prostate patients receiving androgen deprivation therapy (ADT) were exposed group. cancer-free men from general population randomly selected index case birth year county residence, forming unexposed control The participants followed until diagnosis or cancer, death, emigration, end period. adenocarcinoma, squamous-cell carcinoma among ADT-exposed compared was calculated multivariable Cox proportional hazard regression. ratios 95% confidence intervals adjusted for confounders. Results reduction ADT-users non-users (HR 0.49 [95% CI 0.24–0.98]). No such decreased found 1.17 0.60–2.32]), 0.99 0.40–2.46]), squamous cell 0.31–3.13]). Conclusion indicates decreases while no carcinoma.